Hamilton, who has had two cortisone shots in the knee so far this season, will receive another injection after Tuesday's game. This is not an anti-inflammatory but a formula called Synvisc that provides lubrication for the knee.
Hamilton has had this medication injected before.
"He's had these shots infrequently so they usually have a lasting effect," assistant general manager Thad Levine said.
Hamilton has had two operations on the knee in the past and has been bothered by it off-and-on the entire season. There is a possibility that he could require surgery in the off-season but isn't thinking about that right now. He doesn't even want to have an MRI to see what he's dealing with in the knee.
"It's not any different, there's just more pain now than there normally has been," Hamilton said. "The key is to get it calmed down, get the right medication going and get out there playing."
Manager Ron Washington said he is not playing Hamilton on Wednesday. The Rangers are off on Thursday so that will give Hamilton two days of rest before possibly returning to the outfield on Friday. Hamilton will also get at least one day off on the artificial turf in Toronto next week.
Otherwise Washington said he is not concerned about Hamilton's knee.
"Josh is playing tonight and he's played last night," Washington said. "Every now and then Josh will get a DH spot. I'm not making it anything more than what it is. I'm not concerned. After he gets the shot we'll know more."