Beltre has had problems with the artificial turf at Rogers Centre. He was the designated hitter in Monday's 4-1 win to protect his legs from the spongy turf. But he was sore the next day and appeared only as a pinch-hitter in Tuesday's 8-7 loss.
Hamilton left Sunday's game against the Tampa Bay Rays with a stiff back and missed the first two games of the series in Toronto.
Catcher Mike Napoli was in Wednesday's lineup at first base. He did not play in the ninth inning in Tuesday's loss because he had some blurring of his vision in his right eye. The blurring was gone after the game. Napoli was checked by a doctor on Wednesday morning, and the problem was diagnosed as an ocular migraine.
In another lineup change, shortstop Elvis Andrus made his second career start at designated hitter, with Alberto Gonzalez playing shortstop.
The starting lineup had all right-handed hitters against Toronto left-hander Ricky Romero.