Profar, who was dealing with tendinitis in the shoulder for the four weeks of Spring Training, is not expected to need surgery, and the Rangers are hoping to have him back before the All-Star break.
"This is our everyday second baseman, somebody we expected to take a major step forward in his career," assistant general manager Thad Levine said. "Hopefully he'll be a weapon in the second half of the season."
Josh Wilson, who was winning a job as the utility infielder, is the early leading candidate to replace Profar, but the Rangers will review every possible option, including infield prospect Rougned Odor. Other infielders may come available in the final week of Spring Training as teams start cutting down their rosters.
"We'll get somebody there to play," manager Ron Washington said. "We will have a second baseman. We've got guys in camp that can play there. In the meantime, I'm sure [general manager Jon Daniels] will be out there looking. We're OK. Believe me, we're OK. We'll miss Profar, but we'll move on and win some ballgames."
Wilson and Adam Rosales are the primary utility-infield candidates left in camp, but Brent Lillibridge could be brought back from Minor League camp. Wilson is the best defensive player among the candidates and is hitting .267 this spring. He has a career .225 average with a .278 on-base percentage and a .317 slugging percentage.
Kensuke Tanaka wasn't a utility-infield candidate because he doesn't play shortstop, and he was sent back to the Minor Leagues earlier in camp. But he had a 13-year career as a regular second baseman in Japan and was a four-time All-Star.
"We're reviewing everybody's status, including Tanaka," Washington said.
Odor was also in camp earlier this spring before being returned to the Minor Leagues. Odor, rated the No. 4 prospect in the organization by MLB.com, is just 20 years old, and he spent most of 2013 at Class A Advanced Myrtle Beach. But he did play 30 games at Double-A Frisco and hit .306 with six home runs and 19 RBIs.
Asked if the Rangers would consider Odor, Levine said, "I would hate to speculate at this point."
Outside candidates could include Kevin Frandsen, who was just outrighted by the Phillies. The Cardinals might be willing to talk about Pete Kozma, and the Reds have either Ramon Santiago, Chris Nelson or Jason Bourgeois. The Cubs might be willing to move Darwin Barney, and Cesar Izturis could be available if the Astros don't keep him. The same could be true for Jason Donald, who is in camp with the Royals.