It was the ninth umpire challenge of the season by McClendon, with four plays overturned.
The Mariners wound up scoring a run later in the inning with an RBI double by Dustin Ackley to extend their lead to 6-2.
Greg Johns is a reporter for MLB.com. Follow him on Twitter @GregJohnsMLB as well as his Mariners Musings blog. This story was not subject to the approval of Major League Baseball or its clubs.