He went on to record three more hits for a 4-for-4 performance in Texas' 8-2 loss.
Beltre is the 97th player in Major League history to reach 2,500 hits. Jimmy Ryan, who played from 1885 to 1903, is next on the list, with 2,513 hits.
"It's nice to get there," Beltre said. "Maybe when I retire, I'll look back at what I've done, maybe my son can appreciate what I've done. The way I look at it, I try to come out here every day and win ballgames. It's what I do. I can't deny the fact I've collected some things I should be proud of, and I'm looking forward to getting some more."
In addition, Beltre is the sixth player who played the majority of his career at third base to reach the 2,500-hit level. The others are George Brett (3,154), Wade Boggs (3,010), Brooks Robinson (2,848), Chipper Jones (2,726) and Buddy Bell (2,514).
Brett, Boggs and Robinson are in the Hall of Fame; Jones is not yet eligible.
"I think when you play long enough, like I have, you accumulate some stuff, and that's what happened," Beltre said. "If you asked me 10 years ago if I'd be in this situation, I would tell you that you were lying. It's humbling to [be mentioned] with a couple of [those] guys."
T.R. Sullivan is a reporter for MLB.com. Read his blog, Postcards from Elysian Fields, and follow him on Twitter @Sullivan_Ranger. This story was not subject to the approval of Major League Baseball or its clubs.